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M-3814 (Nedisertib)

DNA-dependent protein kinase (DNA-PK) inhibitor
Catalog #: B2217
SKU-Size Size Price Qty
B2217-1 1 mg
B2217-5 5 mg
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Product Details

Alternate Name (S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol; MSC2490484A
Appearance Pale yellow to light green solid
CAS # 1637542-33-6
Molecular Formula C₂₄H₂₁ClFN₅O₃
Molecular Weight 481.91
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C24H21ClFN5O3/c1-33-22-5-4-20(29-30-22)24(32)16-11-17(19(26)12-18(16)25)23-15-3-2-14(10-21(15)27-13-28-23)31-6-8-34-9-7-31/h2-5,10-13,24,32H,6-9H2,1H3/t24-/m0/s1
PubChem CID 86292849
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


M-3814 (Nedisertib) is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration M-3814 binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK

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