A selective TGF-β RI (ALK-5) inhibitor
Catalog #: 2646 | abID:

Product Details

Alternate Name 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284
Appearance Off-white solid
CAS # 396129-53-6
Molecular Formula C₁₇H₁₂N₄
Molecular Weight 272.31
Purity ≥98% by HPLC
Solubility DMSO (~ 25 mg/ml)
InChi InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
PubChem CID 447966
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.

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