Product Details
| Alternate Name | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline; HTS 466284 |
|---|---|
| Appearance | Off-white solid |
| CAS # | 396129-53-6 |
| Molecular Formula | C₁₇H₁₂N₄ |
| Molecular Weight | 272.31 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~ 25 mg/ml) |
| SMILES | C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4 |
| InChi | InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) |
| InChi Key | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
| PubChem CID | 447966 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.
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