Product Details
| abID | ab223886 |
|---|---|
| Alternate Name | N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide |
| Peptide Sequence | No |
| Appearance | White solid |
| CAS # | 1262036-50-9 |
| Molecular Formula | C₁₈H₁₆F₂N₄O₂S |
| Molecular Weight | 390.41 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~10 mg/ml) or Ethanol (<1 mg/ml) |
| SMILES | C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N |
| InChi | InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1 |
| InChi Key | NIDRNVHMMDAAIK-YPMLDQLKSA-N |
| PubChem CID | 49837968 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease.
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