A potent selective β-secretase (BACE-1) inhibitor.
Catalog #: 2299 | abID: ab223886

Product Details

abID ab223886
Alternate Name N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
Peptide Sequence No
Appearance White solid
CAS # 1262036-50-9
Molecular Formula C₁₈H₁₆F₂N₄O₂S
Molecular Weight 390.41
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml) or Ethanol (<1 mg/ml)
InChi InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1
PubChem CID 49837968
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease.

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