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A potent and selective inhibitor of CDK4 and CDK6
Catalog #: B1039
SKU-Size Size Price Qty
B1039-10 10 mg
B1039-50 50 mg
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Product Details

Alternate Name N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine; Abemaciclib
Appearance White to off-white solid
CAS # 1231930-82-7
Molecular Formula C₂₇H₃₂F₂N₈.CH₄O₃S
Molecular Weight 602.7
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml) or H₂O (>60 mg/ml)
InChi InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
PubChem CID 71576678
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models.

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