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A selective IκB kinase inhibitor
Catalog #: B3213
SKU-Size Size Price Qty
B3213-5 5 mg
B3213-25 25 mg
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Product Details

Alternate Name 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-benzo[b]thiophene-4-carboxamide, trihydrochloride
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 946518-60-1
Molecular Formula C₂₄H₂₉ClN₆OS • 3HCl
Molecular Weight 594.4
Purity ≥98% by HPLC
Solubility >10 mg/ml DMSO
InChi InChI=1S/C24H29ClN6OS.3ClH/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16;;;/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29);3*1H
PubChem CID 68856073
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LY-2409881 is a potent and selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases only at ≥10-fold higher concentrations. LY2-409881 inhibits constitutively activated NF-κB, and causes concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells.

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