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A potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3)
Catalog #: B1043
SKU-Size Size Price Qty
B1043-5 5 mg
B1043-25 25 mg
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Product Details

Alternate Name 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
Appearance Off-white to light yellow solid
CAS # 603288-22-8
Molecular Formula C₂₈H₂₅FN₆O₃
Molecular Weight 512.53
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
InChi InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)
PubChem CID 10029385
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LY-2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 1.5 NM for GSK-3α and 0.9 nM for GSK-3β). LY-2090314 plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.

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