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LXR-623

A selective LXR modulator
Catalog #: B2454
SKU-Size Size Price Qty
B2454-5 5 mg
$115.00
B2454-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name WAY-252623; 2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole; WAY252623; LXR623
Appearance White solid
CAS # 875787-07-8
Molecular Formula C₂₁H₁₂ClF₅N₂
Molecular Weight 422.78
Purity ≥98% by HPLC
Solubility >40 mg/ml DMSO
SMILES C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC=C(C=C4)F
InChi InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
InChi Key KYWWJENKIMRJBI-UHFFFAOYSA-N
PubChem CID 16734800
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.


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