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LW6

A potent HIF-1 inhibitor (I
Catalog #: B2277

In stock

SKU-Size Size Price Qty
B2277-5 5 mg
$95.00
B2277-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-benzoic acid, methyl ester; CAY10585
Appearance Off-white solid
CAS # 934593-90-5
Molecular Formula C₂₆H₂₉NO₅
Molecular Weight 435.51
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
InChi InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)
InChi Key BJRPPNOJYFZSLY-UHFFFAOYSA-N
PubChem CID 16124726
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LW6 is a potent HIF-1 inhibitor (IC₅₀ = 4.4 μM). It promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Landau (VHL) without affecting the activity of prolyl hydroxylase (PHD).


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