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A potent and selective positive allosteric modulator at the mGlu5 receptor
Catalog #: B2345

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SKU-Size Size Price Qty
B2345-5 5 mg
B2345-25 25 mg
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Product Details

Alternate Name LSN2814617,5-[(7S)-3-tert-butyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-3-(4-fluorophenyl)-1,2,4-oxadiazole
Appearance Crystalline solid
CAS # 1313498-08-6
Molecular Formula C₁₈H₂₀FN₅O
Molecular Weight 341.39
Purity ≥97% by HPLC
Solubility In DMSO
InChi InChI=1S/C18H20FN5O/c1-18(2,3)17-22-21-14-10-12(8-9-24(14)17)16-20-15(23-25-16)11-4-6-13(19)7-5-11/h4-7,12H,8-10H2,1-3H3
PubChem CID 67300245
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LSN-2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). It acts as a potent and selective potentiator of human and rat mGlu₅ receptors in vitro, displaying curve shift ratios of two to three fold in the concentration-response relationship to glutamate or the glutamate receptor agonist, DHPG, with no detectable intrinsic agonist properties.

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