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LSD1, Human Recombinant

Active human recombinant Lysine (K)-specific demethylase 1 protein
Catalog #: P1659
SKU-Size Size Price Qty
P1659-10 10 μg
P1659-50 50 μg
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Product Details

Alternate Name Lysine-specific histone demethylase, 1KDM1, BHC110, AOF2, KIAA0601, KDM1A, lysine (K)-specific demethylase 1A; Human Recombinant LSD1; LSD, Human Recombinant; Human Recombinant LSD
Accession # BAA25527
Source Sf9 insect cells
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 93.9 kDa (His tag at the N-terminus)
Purity by SDS-PAGE ≥ 95%
Biological Activity ≥ 10 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.

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