Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

LSD1, Human Recombinant

Active human recombinant Lysine (K)-specific demethylase 1 protein
Catalog #: P1659
SKU-Size Size Price Qty
P1659-10 10 μg
$185.00
P1659-50 50 μg
$445.00
More Sizes Get Quote

Product Details

Alternate Name Lysine-specific histone demethylase, 1KDM1, BHC110, AOF2, KIAA0601, KDM1A, lysine (K)-specific demethylase 1A; Human Recombinant LSD1; LSD, Human Recombinant; Human Recombinant LSD
Accession # BAA25527
Source Sf9 insect cells
Appearance Liquid protein
Physical Form Description Liquid
Molecular Weight 93.9 kDa (His tag at the N-terminus)
Purity by SDS-PAGE ≥ 95%
Biological Activity ≥ 10 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.