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Product Details
| Alternate Name | Lysine-specific histone demethylase, 1KDM1, BHC110, AOF2, KIAA0601, KDM1A, lysine (K)-specific demethylase 1A; Human Recombinant LSD1; LSD, Human Recombinant; Human Recombinant LSD |
|---|---|
| Accession # | BAA25527 |
| Source | Sf9 insect cells |
| Appearance | Liquid protein |
| Physical Form Description | Liquid |
| Molecular Weight | 93.9 kDa (His tag at the N-terminus) |
| Purity by SDS-PAGE | ≥ 95% |
| Biological Activity | ≥ 10 mU/mg |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -80°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The mono, di- and trimethylation of particular lysine residues in histone tails (e.g. histone H3 lysine-4 (H3K4), H3K9, H3K27, H3K36, H4K20) are implicated in the transmission of heritable epigenetic information and the control of chromatin structure and DNA transcription. LSD1 catalyzes the oxidative demethylation of mono- and dimethylated H3K4, producing hydrogen peroxide and formaldehyde in the process. H3K4 methylation is considered a transcription activating chromatin mark. In vivo LSD1 is frequently found in association with the transcriptional corepressor protein CoREST and HDACs 1 or 2. Its expression is elevated in a number of cancers, which makes it a promising target for drug development. LSD1 is inhibited by a number of established monoamine oxidase inhibitor drugs.
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