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LRP-5/6 Antibody

based on 1 citations in multiple journalsLRP-5/6 Antibody14.1 4
Catalog #: 3714

In stock

SKU-Size Size Price Qty
3714-30T 30 µg
$89.00
3714-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target LRP-5/6
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 437 of human LRP
Accession # O75197
Gene ID 4041
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control. The antibody recognizes the ~170 kDa full length LRP-5/6 of human and mouse origi
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.


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Caverzasio J and Manen D (2007) Endocrinology 148: 5323-5330.
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