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LRIG1, Mouse Recombinant

Tumor suppressor, negative regulator of the EGF
Catalog #: P1557
SKU-Size Size Price Qty
P1557-10 10 μg
$105.00
P1557-50 50 μg
$495.00
More Sizes Get Quote

Product Details

Alternate Name LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
Gene Symbol Lrig1
Gene ID 16206
Accession # P70193
Source Baculovirus
Appearance Liquid
Physical Form Description Liquid
Molecular Weight 84.8 kDa (His-tag at C terminus)
Purity by SDS-PAGE >90%
Endotoxin Level < 1 EU per 1 ug of protein (determined by LAL method)
Amino Acid Sequence 770 aa (aa 35-796)
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at Cterminus, was expressed in insect cell and purified by using conventional chromatography techniques.


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