A HIV-1 protease inhibitor
Catalog #: 2241 | abID:

Product Details

Alternate Name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Appearance White to off-white solid
CAS # 192725-17-0
Molecular Formula C₃₇H₄₈N₄O₅
Molecular Weight 628.81
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
PubChem CID 92727
MDL Number MFCD04973616
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A protease inhibitor with high specificity for HIV-1 protease. Inhibition of HIV-1 protease (responsible for protein cleavage), results in selectively inhibiting the cleavage of HIV gag and gag-pol polyproteins, thereby preventing viral maturation. It has been reported to reduce morbidity and mortality in a retrospective cohort study of SARS-CoV-2 infection and to reduce lung pathology in non-human primates. It was not associated with reduced viral replication or improved clinical outcome in an open-label randomized clinical trial in patients with COVID-19.

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