Loperamide hydrochloride

A calcium channel blocker and an autophagy inducer
Catalog #: 2683 | abID:

Product Details

Alternate Name 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide hydrochloride
Appearance White solid
CAS # 34552-83-5
Molecular Formula C₂₉H₃₃ClN₂O₂.HCl
Molecular Weight 513.51
Purity ≥98% by titration
Solubility DMSO (>20 mg/ml) or EtOH (>20 mg/ml)
InChi nChI=1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
PubChem CID 71420
MDL Number MFCD00058581
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Loperamide is an antidiarrheal agent that acts as a non-selective Ca²⁺ channel blocker. At nanomolar concentrations (Ki = 2 nM), Loperamide binds to µ-opioid receptors. Also acts as an mTOR-independent autophagy enhancer.

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