Longdaysin

A potent modulator of Circadian Rhythm
Catalog #: B3136 | abID:

Product Details

Alternate Name 9-propan-2-yl-N-[[3-(trifluoromethyl)phenyl]methyl]purin-6-amine; 9-isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
Appearance White powder
CAS # 1353867-91-0
Molecular Formula C₁₆H₁₆F₃N₅
Molecular Weight 335.33
Purity ≥98%
Solubility ~15 mg/ml in DMSO
SMILES CC(C)N1C=NC2=C(N=CN=C21)NCC3=CC(=CC=C3)C(F)(F)F
InChi InChI=1S/C16H16F3N5/c1-10(2)24-9-23-13-14(21-8-22-15(13)24)20-7-11-4-3-5-12(6-11)16(17,18)19/h3-6,8-10H,7H2,1-2H3,(H,20,21,22)
InChi Key REKSFCCYDQMSIN-UHFFFAOYSA-N
PubChem CID 49830252
MDL Number MFCD20527323
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20 ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Longdaysin is a potent modulator of circadian rhythm. It slows the circadian clock both in cultured mammalian cells and zebrafish. It inhibits the protein kinases CKIδ, CKIα, ERK2, and CDK7 activities with IC₅₀ values of 8.8 µM, 5.6 µM, 52 µM and 29 µM, respectively.


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