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LLY-507

A potent, cell-permeable, small molecule inhibitor of SMYD2
Catalog #: B1111
SKU-Size Size Price Qty
B1111-1 1 mg
$75.00
B1111-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 5-Cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide
Appearance Crystalline solid
CAS # 1793053-37-8
Molecular Formula C₃₆H₄₂N₆O
Molecular Weight 574.8
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6
InChi InChI=1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)
InChi Key PNYRDVBFYVDJJI-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LLY-507 is a potent, cell-permeable, small molecule inhibitor of SMYD2 (IC₅₀ = 15 nM), a lysine N-methyltransferase.  It has been shown to inhibit p53 lysine monomethylation in KYSE-150 esophageal squamous cell carcinoma cells stably expressing SMYD2 with an IC₅₀ value of 0.6 µM. LLY-507 is >100-fold selective for SMYD2 over a panel of 27 protein methyltransferases and non-methyltransferase targets.


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