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Lithocholic acid

A detergent and an endogenous inhibitor of MDM2 and MDM4
Catalog #: 2187
SKU-Size Size Price Qty
2187-1G 1 g
$60.00
2187-5G 5 g
$205.00
More Sizes Get Quote

Product Details

Alternate Name 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol; LCA
Appearance White to off-white solid
CAS # 434-13-9
Molecular Formula C₂₄H₄₀O₃
Molecular Weight 376.57
Purity ≥97% by TLC
Solubility DMSO or EtOH
SMILES CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
InChi InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1
InChi Key SMEROWZSTRWXGI-HVATVPOCSA-N
PubChem CID 9903
MDL Number MFCD00003682
Handling Protect from air and moisture
Storage Conditions RT
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Lithocholic acid (LCA) is a hydrophobic secondary bile acid that is primarily formed in the intestine by the bacterial 7-α dehydroxylation of chenodeoxycholic acid. Acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4.


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