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LIT-927

A potent and selective CXCL12 neutraligand
Catalog #: B2432

In stock

SKU-Size Size Price Qty
B2432-5 5 mg
$115.00
B2432-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one, LIT927
Appearance Crystalline solid
CAS # 2172879-52-4
Molecular Formula C₁₇H₁₃ClN₂O₃
Molecular Weight 328.75
Purity ≥98% by HPLC
Solubility >10 mg/ml in DMSO
SMILES COC1=C(C=CC(=C1)C2=NC(=O)NC(=C2)C3=CC=C(C=C3)Cl)O
InChi InChI=1S/C17H13ClN2O3/c1-23-16-8-11(4-7-15(16)21)14-9-13(19-17(22)20-14)10-2-5-12(18)6-3-10/h2-9,21H,1H3,(H,19,20,22)
InChi Key BYYRNPIGDRRGLJ-UHFFFAOYSA-N
PubChem CID 137287575
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LIT-927 is a locally and orally active CXCL12 neutraligand (Ki = 267 nM for CXCL12-TR binding). Displays anti-inflammatory effect in a murine model of allergic airway hypereosinophilia.


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