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Liproxstatin-1

A ferroptosis inhibitor
Catalog #: B2312

In stock

SKU-Size Size Price Qty
B2312-5 5 mg
$85.00
B2312-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
Appearance White to off-white solid
CAS # 950455-15-9
Molecular Formula C₁₉H₂₁ClN₄
Molecular Weight 340.85
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES C1CNCCC12C(=NC3=CC=CC=C3N2)NCC4=CC(=CC=C4)Cl
InChi InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChi Key YAFQFNOUYXZVPZ-UHFFFAOYSA-N
PubChem CID 20931416
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.


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