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LIMKi 3

LIMKi 3 is a potent inhibitor of LIMK1 and LIMK2
Catalog #: B1095
SKU-Size Size Price Qty
B1095-5 5 mg
$125.00
B1095-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide ; BMS 5
Appearance White Solid
CAS # 1338247-35-0
Molecular Formula C₁₇H₁₄Cl₂F₂N₄OS
Molecular Weight 431.29
Purity ≥98% by HPLC
Solubility DMSO (>40mg/ml)
SMILES CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F
InChi InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)
InChi Key IVUGBSGLHRJSSP-UHFFFAOYSA-N
PubChem CID 56965901
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin polymerization or inducing cytotoxicity. It also reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.


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