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New

LIGHT, Human Recombinant

Apoptosis inducer
Catalog #: P1291

In stock

SKU-Size Size Price Qty
P1291-3 3 μg
$115.00
P1291-15 15 μg
$295.00
More Sizes Get Quote

Product Details

Alternate Name TNFSF14, HVEM-L, Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, Herpesvirus entry mediator ligand, CD258, LIGHT
Accession # O43557
Source Hi-5 Insect cells
Appearance Lyophilized
Physical Form Description Lyophilized from 20 mM Sodium Phosphate, pH 7.0.
Molecular Weight 20.0-22.5 kDa
Purity by SDS-PAGE ≥ 95%
Endotoxin Level <0.1 EU/μg
Biological Activity Determined by its cytotoxic effect on HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-gamma.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFκB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Due to glycosylation LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.


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