A dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2
Catalog #: B3028 | abID:

Product Details

Alternate Name LIK066; (2S,3R,4R,5S,6R)-2-[3-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-4-ethylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,4R,5S,6R)-2-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
Appearance Solid
CAS # 1291094-73-9
Molecular Formula C₂₃H₂₈O₇
Molecular Weight 416.46
Purity ≥98%
Solubility Soluble in DMSO
InChi InChI=1S/C23H28O7/c1-2-14-4-5-15(23-22(27)21(26)20(25)19(12-24)30-23)11-16(14)9-13-3-6-17-18(10-13)29-8-7-28-17/h3-6,10-11,19-27H,2,7-9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1
PubChem CID 52913524
MDL Number MFCD31630771
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Licogliflozin is a dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2 with a higher selectivity for SGLT2 (in vitro IC₅₀ values of 20.6 and 0.58 nM, respectively). It causes a reduction in body weight from baseline versus placebo after 24 weeks (50 mg twice daily). However, the percent decreases were numerically small (<5%). Higher doses of licogliflozin also reduce waist circumference, fasting plasma glucose, hemoglobin A1c (HbA1c), systolic blood pressure and triglycerides. It increases HDL cholesterol and 24‐hour urinary glucose excretion.

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