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Anti-LGR5 Antibody

Polyclonal Antibody to detect LGR5 in Human, mouse and rat samples.
Catalog #: A1007
$280.00

Product Details

Cat # +Size A1007-100
Size 100 µl
Antibody Target LGR5
Alternate Name Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen synthetic human LGR5 peptide (Ile685 - Pro720)
Accession # O75473
Gene ID 8549
Appearance Colorless liquid
Formulation 100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Affinity purified rabbit IgG
Species Reactivity Human, Mouse, Rat
Application Western Blot, Immunofluorescent staining, Immunohistochemistry, Flow cytometry
Positive Control Western blot
Application & Usage Western Blot 1:1000; Immunofluorescent staining 1:100; Immunohistochemistry 1:25; Flow cytometry 1:25
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.


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