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LGK974

A potent Porcupine (porcin) inhibitor
Catalog #: 2645
SKU-Size Size Price Qty
2645-1 1 mg
$85.00
2645-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
Appearance Crystalline solid
CAS # 1243244-14-5
Molecular Formula C₂₃H₂₀N₆O
Molecular Weight 396.44
Purity ≥98% by HPLC
Solubility DMSO (~ 35 mg/ml)
SMILES CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
InChi InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChi Key XXYGTCZJJLTAGH-UHFFFAOYSA-N
PubChem CID 46926973
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.


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