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LF3

A potent and specific inhibitor of canonical Wnt signaling
Catalog #: B2644
SKU-Size Size Price Qty
B2644-5 5 mg
$115.00
B2644-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-
Appearance White to off-white solid
CAS # 664969-54-4
Molecular Formula C₂₀H₂₄N₄O₂S₂
Molecular Weight 416.56
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES C1CN(CCN1CC=CC2=CC=CC=C2)C(=S)NC3=CC=C(C=C3)S(=O)(=O)N
InChi InChI=1S/C20H24N4O2S2/c21-28(25,26)19-10-8-18(9-11-19)22-20(27)24-15-13-23(14-16-24)12-4-7-17-5-2-1-3-6-17/h1-11H,12-16H2,(H,22,27)(H2,21,25,26)/b7-4+
InChi Key ZUQIFHLBPBLRRM-QPJJXVBHSA-N
PubChem CID 1213452
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of cancer stem cells (CSCs).


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