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Leucine-rich Alpha 2 Glycoprotein-1 (LRG1), Human Plasma

An initiator/amplifier of programmed cell death (apoptosis)
Catalog #: P1431

Product Details

Cat # +Size P1431-50
Size 50 µg
Alternate Name Leucine-rich alpha-2-glycoprotein, LRG, LRG1
Gene Symbol LRG1
Gene ID 116844
Accession # P02750
Source Human Plasma
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 50,000
Purity by SDS-PAGE >95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LRG1 binds cytochrome c, an initiator/amplifier of programmed cell death (apoptosis), and by binding cytochrome c, is thought to play a role in cell survival. LRG1 is a biomarker associated with several cancers, including non-small cell lung cancer, colorectal cancer, and pancreatic cancer. Recent studies have shown it is three-fold more abundant in ovarian cancer serum compared to non-cancer control serum. LRG1 levels are only moderately correlated with CA125 levels. Elevated levels of LRG1 in the cerebral spinal fluid are being studied as markers for the early diagnosis of Parkinson's disease and progressive supranuclear palsy. In normal plasma, LRG1 has a concentration of 21-50 ug/ml. It is an acute phase protein with levels elevated in patients with bacterial infections; interestingly, during the inflammatory response, LRG1 levels are not correlated with CRP levels.

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