Product Details
| abID | ab285403 |
|---|---|
| Alternate Name | (5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one |
| Appearance | Beige solid |
| CAS # | 1112978-84-3 |
| Molecular Formula | C₁₇H₁₃N₃O₃ |
| Molecular Weight | 307.3 |
| Purity | >98% by NMR |
| Solubility | DMSO or EtOH |
| SMILES | O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3 |
| InChi | InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8- |
| InChi Key | PGPHHJBZEGSUNE-JYRVWZFOSA-N |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
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Steven E. Guard, The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. Sci Rep, April 2019; 31024071.
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