Leucettine L41

A potent inhibitor of DYRKs and CLKs
Catalog #: 2617 | abID: ab285403

Product Details

abID ab285403
Alternate Name (5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
Appearance Beige solid
CAS # 1112978-84-3
Molecular Formula C₁₇H₁₃N₃O₃
Molecular Weight 307.3
Purity >98% by NMR
Solubility DMSO or EtOH
InChi InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.

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Steven E. Guard, The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. Sci Rep, April 2019;  31024071.
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