Product Details
| abID | ab142107 |
|---|---|
| Alternate Name | CEP-701; KT-5555; SPM-924 |
| Appearance | Colorless solid |
| CAS # | 111358-88-4 |
| Molecular Formula | C₂₆H₂₁N₃O₄ |
| Molecular Weight | 439.46 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mg/ml) and Ethanol (20 mg/ml) |
| SMILES | CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O |
| InChi | InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 |
| InChi Key | UIARLYUEJFELEN-LROUJFHJSA-N |
| PubChem CID | 126565 |
| MDL Number | MFCD12828858 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.
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