A PTK inhibitor
Catalog #: 1805 | abID: ab142107

Product Details

abID ab142107
Alternate Name CEP-701; KT-5555; SPM-924
Appearance Colorless solid
CAS # 111358-88-4
Molecular Formula C₂₆H₂₁N₃O₄
Molecular Weight 439.46
Purity ≥98% by HPLC
Solubility DMSO (100 mg/ml) and Ethanol (20 mg/ml)
InChi InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
PubChem CID 126565
MDL Number MFCD12828858
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


An indolocarbazole derivative with antineoplastic properties. Acts as a potent inhibitor of several tyrosine kinases including FLT3, JAK2, and TrkA with IC₅₀ values of 3, 1, and <25 nM, respectively. It suppresses JAK2/STAT5 signaling and is effective against myeloproliferative disorders in vivo.

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