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A non-nucleoside reverse transcriptase inhibitor
Catalog #: B3305
SKU-Size Size Price Qty
B3305-5 5 mg
B3305-25 25 mg
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Product Details

Alternate Name UK-453,061 5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]-1,3-benzenedicarbonitrile
Appearance Off-white to yellow to light brown powder
CAS # 473921-12-9
Molecular Formula C₁₇H₁₈N₄O₂
Molecular Weight 310.35
Purity ≥98%
Solubility ~30 mg/ml DMSO
InChi InChI=1S/C17H18N4O2/c1-3-15-17(16(4-2)21(20-15)5-6-22)23-14-8-12(10-18)7-13(9-14)11-19/h7-9,22H,3-6H2,1-2H3
PubChem CID 16739244
MDL Number MFCD16619314
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Lersivirine is a non-nucleoside, next generation reverse transcriptase inhibitor (IC50 = 118 nM for the wild-type HIV-1 enzyme). It inhibits a panel of 14 single-point mutant HIV-1 reverse transcriptases with mean IC50 values within 10-fold of the wild-type enzyme. Lersivirine inhibits HIV-1 virus replication in MT-2 cells with EC50 values of 5.04, 13.1, and 34.9 nM at multiplicities of infection (MOIs) of 0.005, 0.05, and 0.5, respectively, and displays synergistic or additive effects when used in combination with a variety of antiretroviral agents.

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