Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Lersivirine

A non-nucleoside reverse transcriptase inhibitor
Catalog #: B3305
SKU-Size Size Price Qty
B3305-5 5 mg
$125.00
B3305-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name UK-453,061 5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]-1,3-benzenedicarbonitrile
Appearance Off-white to yellow to light brown powder
CAS # 473921-12-9
Molecular Formula C₁₇H₁₈N₄O₂
Molecular Weight 310.35
Purity ≥98%
Solubility ~30 mg/ml DMSO
SMILES CCC1=C(C(CC)=NN1CCO)OC2=CC(C#N)=CC(C#N)=C2
InChi InChI=1S/C17H18N4O2/c1-3-15-17(16(4-2)21(20-15)5-6-22)23-14-8-12(10-18)7-13(9-14)11-19/h7-9,22H,3-6H2,1-2H3
InChi Key MCPUZZJBAHRIPO-UHFFFAOYSA-N
PubChem CID 16739244
MDL Number MFCD16619314
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Lersivirine is a non-nucleoside, next generation reverse transcriptase inhibitor (IC50 = 118 nM for the wild-type HIV-1 enzyme). It inhibits a panel of 14 single-point mutant HIV-1 reverse transcriptases with mean IC50 values within 10-fold of the wild-type enzyme. Lersivirine inhibits HIV-1 virus replication in MT-2 cells with EC50 values of 5.04, 13.1, and 34.9 nM at multiplicities of infection (MOIs) of 0.005, 0.05, and 0.5, respectively, and displays synergistic or additive effects when used in combination with a variety of antiretroviral agents.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.