Leptin, rat recombinant

Adipose-derived hormone which regulates energy intake & energy expenditure
Catalog #: 4368 | abID:

Product Details

Alternate Name OB Protein, Obesity Protein, OBS, Obesity factor.
Gene Symbol LEP
Gene ID 25608
Accession # P50596
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 4.5 µM NaHCO₃.
Molecular Weight 16.2 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ determined by the leptin-dependent stimulation of human OB-R transfected murine BaF3 indicator cells is 0.35-0.06 ng/ml.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for three months. For long-term storage it is recommended to add a carrier protein (0.1% HAS or BSA
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body’s fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.

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Almabhouh, Fayez A. et al. (2016) Melatonin ameliorates the adverse effects of leptin on sperm, Asian J Androl. 2016 Oct 14.
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