Product Details
| Alternate Name | OB Protein, Obesity Protein, OBS, Obesity factor. |
|---|---|
| Gene Symbol | LEP |
| Gene ID | 25608 |
| Accession # | P50596 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from 4.5 µM NaHCO₃. |
| Molecular Weight | 16.2 kDa |
| Purity by SDS-PAGE | ≥95% |
| Purity by | ≥95% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | The ED₅₀ determined by the leptin-dependent stimulation of human OB-R transfected murine BaF3 indicator cells is 0.35-0.06 ng/ml. |
| Reconstitution Instructions | Reconstitute in H₂O to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for three months. For long-term storage it is recommended to add a carrier protein (0.1% HAS or BSA |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body’s fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.
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Almabhouh, Fayez A. et al. (2016) Melatonin ameliorates the adverse effects of leptin on sperm, Asian J Androl. 2016 Oct 14.
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