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Leniolisib

A potent and selective PI3Kδ inhibitor
Catalog #: B2435

In stock

SKU-Size Size Price Qty
B2435-1 1 mg
$155.00
B2435-5 5 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name 1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-
Appearance Crystalline solid
CAS # 1354690-24-6
Molecular Formula C₂₁H₂₅F₃N₆O₂₅
Molecular Weight 450.46
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CN=C(C(=C4)C(F)(F)F)OC
InChi InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23) 24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1
InChi Key MWKYMZXCGYXLPL-ZDUSSCGKSA-N
PubChem CID 57495353
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Leniolisib is a potent and selective PI3Kδ inhibitor with an IC₀ of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular selectivity over PI3Kα. Inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells in vitro.


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