An immunosuppressant and a Tyrosine kinase inhibitor
Catalog #: 1972 | abID: ab141479

Product Details

abID ab141479
Alternate Name 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide; HWA486,
Appearance White to off-white solid
CAS # 75706-12-6
Molecular Formula C₁₂H₉F₃N₂O₂
Molecular Weight 270.21
Purity ≥98% by HPLC
Solubility DMSO (100 mM) or Ethanol (100 mM)
InChi InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
PubChem CID 3899
MDL Number MFCD00867593
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNF-dependent NF-κB activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.

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