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LDN193189 HCl

A potent BMP type I receptor inhibitor
Catalog #: 1995
SKU-Size Size Price Qty
1995-5 5 mg
$195.00
1995-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline;hydrochloride; DM-3189 (hydrochloride).
Appearance Yellow solid
CAS # 1062368-62-0
Molecular Formula C₂₅H₂₂N₆.HCl
Molecular Weight 442.94
Purity ≥97% by HPLC
Solubility DMSO (10 mM)
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl
InChi InChI=1S/C25H22N6.ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;/h1-10,15-17,26H,11-14H2;1H
InChi Key PCCDKTWDGDFRME-UHFFFAOYSA-N
PubChem CID 54613581
MDL Number MFCD17392570
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. LDN193189 HCl is a small molecule inhibitor of BMP type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively).It only weakly inhibits ALK4, ALK5, and ALK7. LDN193189 HCl functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN193189 HCl has been used to reduce ectopic ossification in a mouse model. The role of BMP2 signals in the growth and angiogenesis of non-small-cell lung carcinoma (NSCLC) also suggest LDN-193189 may be a potent inhibitor of lung tumors.


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