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Product Details
| Alternate Name | 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444 |
|---|---|
| Appearance | Yellow solid |
| CAS # | 668467-91-2 |
| Molecular Formula | C₁₇H₁₁Cl₃N₂O₃ |
| Molecular Weight | 397.64 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (20 mg/ml) |
| SMILES | CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl |
| InChi | InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16- |
| InChi Key | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
| PubChem CID | 16760696 |
| MDL Number | MFCD09037562 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.
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