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LDN-57444

A selective UCHL1 inhibitor
Catalog #: 2016
SKU-Size Size Price Qty
2016-5 5 mg
$75.00
2016-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Appearance Yellow solid
CAS # 668467-91-2
Molecular Formula C₁₇H₁₁Cl₃N₂O₃
Molecular Weight 397.64
Purity ≥98% by TLC
Solubility DMSO (20 mg/ml)
SMILES CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChi InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChi Key OPQRFPHLZZPCCH-PGMHBOJBSA-N
PubChem CID 16760696
MDL Number MFCD09037562
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.


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