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An inhibitor of BMP receptor 1
Catalog #: B3067
SKU-Size Size Price Qty
B3067-5 5 mg
B3067-25 25 mg
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Product Details

Alternate Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; DM-3189
Appearance Light yellow to yellow powder
CAS # 1062368-24-4
Molecular Formula C₂₅H₂₂N₆
Molecular Weight 406.5
Purity ≥98%
Solubility 0.2 mg/ml in ethanol (may need warming and sonication)
InChi InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
PubChem CID 25195294
MDL Number MFCD17169988
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C. Store in the dark. Product is light sensitive. Protect from air. Store under desiccating conditions.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC₅₀≥ 500 nM). It inhibits the activation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 in a dose-dependent manner in C2C12 cells. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors.

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