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LDN-193189

An inhibitor of BMP receptor 1
Catalog #: B3067
SKU-Size Size Price Qty
B3067-5 5 mg
$145.00
B3067-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; DM-3189
Appearance Light yellow to yellow powder
CAS # 1062368-24-4
Molecular Formula C₂₅H₂₂N₆
Molecular Weight 406.5
Purity ≥98%
Solubility 0.2 mg/ml in ethanol (may need warming and sonication)
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
InChi InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChi Key CDOVNWNANFFLFJ-UHFFFAOYSA-N
PubChem CID 25195294
MDL Number MFCD17169988
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C. Store in the dark. Product is light sensitive. Protect from air. Store under desiccating conditions.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC₅₀≥ 500 nM). It inhibits the activation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 in a dose-dependent manner in C2C12 cells. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors.


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