Product Details
| Alternate Name | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline,dihydrochloride |
|---|---|
| Appearance | Yellow Powder |
| CAS # | 1435934-00-1 |
| Molecular Formula | C₂₅H₂₄Cl₂N₆ |
| Molecular Weight | 479.409 |
| Purity | >98% |
| Solubility | ~5 mg/ml in DMSO |
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl |
| InChi | InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H |
| InChi Key | CMQXLLAILGGLRV-UHFFFAOYSA-N |
| PubChem CID | 91900717 |
| MDL Number | MFCD23098917 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7. It inhibits phosphorylation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 with IC₅₀ value of 5 nM. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors.
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