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LDN-193189 dihydrochloride

An inhibitor of BMP receptor 1
Catalog #: B2986
SKU-Size Size Price Qty
B2986-1 1 mg
$65.00
B2986-5 5 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline,dihydrochloride
Appearance Yellow Powder
CAS # 1435934-00-1
Molecular Formula C₂₅H₂₄Cl₂N₆
Molecular Weight 479.409
Purity >98%
Solubility ~5 mg/ml in DMSO
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl
InChi InChI=1S/C25H22N6.2ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;;/h1-10,15-17,26H,11-14H2;2*1H
InChi Key CMQXLLAILGGLRV-UHFFFAOYSA-N
PubChem CID 91900717
MDL Number MFCD23098917
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7. It inhibits phosphorylation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 with IC₅₀ value of 5 nM. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors.


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