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LDN-192960 hydrochloride

A Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) inhibitor
Catalog #: B3285
SKU-Size Size Price Qty
B3285-5 5 mg
B3285-25 25 mg
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Product Details

Alternate Name 3-[(2,7-dimethoxy-9-acridinyl)thio]-1-propanamine, dihydrochloride
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2309172-48-1
Molecular Formula C₁₈H₂₀N₂O₂S • 2HCl
Molecular Weight 401.4
Purity ≥98%
Solubility >30 mg/ml DMSO
InChi InChI=1S/C18H20N2O2S.2ClH/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16;;/h4-7,10-11H,3,8-9,19H2,1-2H3;2*1H
PubChem CID 91885401
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It displays selectivity for Haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM).

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