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LDLR Antibody

based on 1 citations in multiple journalsLDLR Antibody14.1 4
Catalog #: 3839
SKU-Size Size Price Qty
3839-30T 30 µg
$95.00
3839-100 100 µg
$335.00
More Sizes Get Quote

Product Details

Antibody Target LDLR
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding amino acids 850 of human LDLR
Accession # P01130
Gene ID 3949
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human, mouse, rat, bovine, hamster
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes mature LDLR (160 kDa), LDLR precursor (120 kDa) and LDLR monomer (~50 kDa).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Low density lipoprotein receptors (LDLR) are cell surface glycoproteins that regulate LDL cholesterol by scavenging LDL from the blood. LDLR is characterized by a cluster of cysteine-rich class A repeats, EGF-like repeats, the O-linked sμgars domain and six YWTD or class B repeats. Mutations in the LDLR gene cause autosomal dominant disease such as familial hypercholesterolemia (FH) and atherosclerosis.


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Goettsch, Claudia et al. (2016) A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification, Atherosclerosis. 2016 Aug;251:109-118.
Dong, Bin et al. (2017) Hepatic HNF1 transcription factors control the induction of PCSK9 mediated by rosuvastatin in normolipidemic hamsters, Int J Mol Med. 2017 Mar;39(3):749-756.
Shende et al., Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice. J. Lipid Res., Apr 2015; 56: 801 - 809.
Singh et al., A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression. J. Lipid Res., Jul 2014; 55: 1397 - 1407.
Trushina et al., Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo.Hum. Mol. Genet., Jan 2014; 23: 129 - 144.
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