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A highly potent anaplastic lymphoma kinase (ALK) inhibitor
Catalog #: B1928
SKU-Size Size Price Qty
B1928-5 5 mg
B1928-25 25 mg
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Product Details

Alternate Name 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine; Ceritinib
Appearance Crystalline solid
CAS # 1032900-25-6
Molecular Formula C₂₈H₃₆ClN₅O₃S
Molecular Weight 558.14
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
PubChem CID 57379345
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


LDK-378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 200 pM). It displays weaker inhibition against IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively), and is minimally effective against a panel of other kinases.

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