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LC3 (APG8B) (NT) Antibody

Polyclonal antibody to detect LC3 in human, rat and bovine samples
Catalog #: 6946
$285.00

Product Details

Cat # +Size 6946-100
Size 100 µl
Antibody Target LC3
Alternate Name MAP1LC3B; MAP1ALC3; Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta.
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit Ig
Immunogen This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human.
Accession # Q9GZQ8
Gene ID 81631
Appearance Colorless liquid
Formulation Supplied in PBS with 0.09% (W/V) sodium azide.
Purification Ammonium sulphate precipitated and dialyzed Antibody
Species Reactivity Human, Rat. Predicted cross reactivity with bovine samples.
Application Western blot, Immunohistochemistry, IF
Positive Control WB: HepG2 and NIH 3T3 cell lysate, IHC: brain sections, IF: U251 cells
Application & Usage WB: 1:1000, IF: 1:100, IHC: 1:50-100.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.


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