Anti-LC3 (APG8) Monoclonal Antibody (Clone 166AT1234)

Monoclonal antibody to detect LC3 in human, mouse and rat samples
Catalog #: 3233 | abID:

Product Details

Cat # +Size 3233-100
Size 100 µl
Antibody Target LC3
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1-Kappa
Immunogen This antibody is generated from mouse immunized with a full length recombinant protein of human LC3 (APG8).
Accession # Q9H492
Gene ID 84557
Appearance Colorless liquid
Formulation Supplied in PBS with 0.09% (W/V) sodium azide.
Purification Protein G purification
Species Reactivity Human, Mouse, Rat
Application & Usage Western blot: 1:8000 dilution
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.


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