Product Details
| Cat # +Size | 3233-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | LC3 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1-Kappa |
| Immunogen | This antibody is generated from mouse immunized with a full length recombinant protein of human LC3 (APG8). |
| Accession # | Q9H492 |
| Gene ID | 84557 |
| Appearance | Colorless liquid |
| Formulation | Supplied in PBS with 0.09% (W/V) sodium azide. |
| Purification | Protein G purification |
| Species Reactivity | Human, Mouse, Rat |
| Application & Usage | Western blot: 1:8000 dilution |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
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