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Lazertinib

A potent, irreversible third-generation EGFR tyrosine kinase inhibitor
Catalog #: B2348

In stock

SKU-Size Size Price Qty
B2348-5 5 mg
$165.00
B2348-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
Appearance White to off-white solid
CAS # 1903008-80-9
Molecular Formula C₃₀H₃₄N₈O₃
Molecular Weight 554.66
Purity ≥98% by HPLC
Solubility >25 mg/ml (DMSO)
SMILES CN(C)CC1=CN(N=C1C2=CC=CC=C2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
InChi InChI=1S/C30H34N8O3/c1-5-28(39)32-23-17-24(26(40-4)18-25(23)37-13-15-41-16-14-37)33-30-31-12-11-27(34-30)38-20-22(19-36(2)3)29(35-38)21-9-7-6-8-10-21/h5-12,17-18,20H,1,13-16,19H2,2-4H3,(H,32,39)(H,31,33,34)
InChi Key RRMJMHOQSALEJJ-UHFFFAOYSA-N
PubChem CID 121269225
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, third-generation, selective inhibitor of certain forms of the epidermal growth factor receptor (EGFR) with activating mutations, with potential antineoplastic activity. Upon administration, lazertinib specifically and irreversibly binds to and inhibits selective EGFR mutants, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Lazertinib may inhibit programmed cell death-1 ligand 1 (PD-L1) and inflammatory cytokines in specific cancer cells harboring certain EGFR mutations.


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