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A DNA topoisomerase I inhibitor and a histone demethylase (HDM) inhibitor
Catalog #: 2262
SKU-Size Size Price Qty
2262-5 5 mg
2262-25 25 mg
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Product Details

Alternate Name 3,4-Dihydro-2,2-dimethyl-2H-naphtho­[1,2-b]pyran-5,6-dione
Peptide Sequence No
Appearance Orange solid
CAS # 4707-32-8
Molecular Formula C₁₅H₁₄O₃
Molecular Weight 242.27
Purity ≥98% by TLC
Solubility DMSO (100 mM) or EtOH (50 mM)
InChi InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
PubChem CID 3885
MDL Number MFCD01712233
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM).

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