Product Details
| Alternate Name | 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione |
|---|---|
| Peptide Sequence | No |
| Appearance | Orange solid |
| CAS # | 4707-32-8 |
| Molecular Formula | C₁₅H₁₄O₃ |
| Molecular Weight | 242.27 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (100 mM) or EtOH (50 mM) |
| SMILES | CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C |
| InChi | InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3 |
| InChi Key | QZPQTZZNNJUOLS-UHFFFAOYSA-N |
| PubChem CID | 3885 |
| MDL Number | MFCD01712233 |
| Handling | Protect from light and mositure |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM).
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