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LAMP-2 Antibody (CT)

Catalog #: 5078
$325.00

Product Details

Cat # +Size 5078-100
Size 100 µg
Antibody Target LAMP-2
Alternate Name LAMP-2, Lysosome associated membrane protein 2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen LAMP-2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LAMP-2.
Accession # P13473
Gene ID 3920
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column.
Species Reactivity Human, mouse
Application Western blot, Immunocytochemistry, ELISA
Positive Control Western Blot: HepG2 cell lysateImmunocytochemistry: HepG2 cells
Application & Usage Western Blot: 1 - 2 μg/ml, Immunocytochemistry: 10 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.


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