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LAMP-1 Antibody (Center)

Catalog #: 5077
$325.00

Product Details

Cat # +Size 5077-100
Size 100 µg
Antibody Target LAMP-1
Alternate Name LAMP-1, Lysosome associated membrane protein 1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.
Accession # P11279
Gene ID 3916
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column.
Species Reactivity Human, mouse, rat
Application Western blot, Immunofluorescence, ELISA
Positive Control Western Blot: EL4 cell lysateImmunofluorescence: Human colon tissue
Application & Usage Western Blot: 1 - 2 μg/ml, Immunofluorescence: 20 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thoμght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, sμggesting that each protein possesses some unique and necessary functions.


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