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Lamin A Antibody

Catalog #: 3267
SKU-Size Size Price Qty
3267-30T 30 µg
$89.00
3267-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Lamin A
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 220 of human Lamin A
Accession # BC033088
Gene ID 4000
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-Lamin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Application & Usage Western blot analysis (0.5-4 µg/ml) and Immunohistochemistry (15-20 µg/ml). However, the optimal conditions should be determined individually. The antibody mainly detects full length (~70 kDa) and in a much lesser extent the cleaved fragments (45 kDa and
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin A is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70 kDa lamin A is cleaved to a large (40-45 kDa) and small (23 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.


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