Lactacystin (Synthetic)

A proteasome inhibitor
Catalog #: 1709 | abID: ab141411

Product Details

abID ab141411
Cat # +Size 1709-200
Size 200 µg
Alternate Name 2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid
Appearance White solid
CAS # 133343-34-7
Molecular Formula C₁₅H₂₄N₂O₇S
Molecular Weight 376.42
Purity ≥95% by HPLC
Solubility DMSO (25 mg/ml)
InChi InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)
PubChem CID 3870
MDL Number MFCD01076525
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).

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