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L002

An inhibitor of p300 histone acetyltransferase
Catalog #: B2859
SKU-Size Size Price Qty
B2859-1 1 mg
$55.00
B2859-5 5 mg
$175.00
More Sizes Get Quote

Product Details

Alternate Name [(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate; 4-(4-methoxyphenylsulfonyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone; (3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino 4-methoxybenzene-1-sulfonate; (3,5-dimethyl-4-oxocyclohexa-2,5-dienylidene)azamethyl 4-methoxybenzenesulfonate; 2,6-dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; NSC764414; p300/CBP Inhibitor VI
Appearance A crystalline solid
CAS # 321695-57-2
Molecular Formula C₁₅H₁₅NO₅S
Molecular Weight 321.35
Purity ≥98%
Solubility ~1 mg/ml in Ethanol
~30 mg/ml in DMSO and DMF
SMILES CC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C
InChi InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3
InChi Key VEWFTYOFWIXCIO-UHFFFAOYSA-N
PubChem CID 2221149
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.


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